Corticotrophin releasing factor: effects on circulating gut and pancreatic peptides in man.

Journal article

As a CRF-like peptide has been isolated from human gut, we investigated the effect of synthetic CRF-41 100 micrograms on gut and pancreatic peptides in six normal subjects. There was a significant rise in pancreatic polypeptide compared to a control infusion, but no change in plasma insulin, pancreatic glucagon, gastrin, somatostatin, motilin, neurotensin, gastric inhibitory peptide, or cholecystokinin was seen. In addition, there was no change in circulating met-enkephalin. We conclude that the rise in pancreatic polypeptide seen after CRF administration may suggest a role for a CRF-like peptide in the control of pancreatic function.

Authors: Lytras, N; Grossman, A; Rees, L; Schally, A; Bloom, SR

• Publication status: Published
• Journal: Clinical endocrinology
• Volume: 20
• Issue: 6
• Pages: 725-729
• Publication date: 1984-06-01
• DOI: 10.1111/j.1365-2265.1984.tb00123.x
• EISSN: 1365-2265
• ISSN: 0300-0664
• Language: English
• Keywords: Gastrins; Hydrocortisone; Humans; Cholecystokinin; Pancreas; Pancreatic Polypeptide; Motilin; Enkephalin, Methionine; Somatostatin; Gastric Inhibitory Polypeptide; Neurotensin; Insulin; Hormones; Glucagon; Male; Corticotropin-Releasing Hormone; Adult