Population pharmacokinetic and pharmacodynamic properties of intramuscular quinine in Tanzanian children with severe Falciparum malaria.

Journal article

Although artesunate is clearly superior, parenteral quinine is still used widely for the treatment of severe malaria. A loading-dose regimen has been recommended for 30 years but is still often not used. A population pharmacokinetic study was conducted with 75 Tanzanian children aged 4 months to 8 years with severe malaria who received quinine intramuscularly; 69 patients received a loading dose of 20 mg quinine dihydrochloride (salt)/kg of body weight. Twenty-one patients had plasma quinine ...

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Authors: Hendriksen, I; Maiga, D; Lemnge, M; Mtove, G; Gesase, S

• Publication status: Published
• Journal: Antimicrobial agents and chemotherapy
• Volume: 57
• Issue: 2
• Pages: 775-783
• Publication date: 2013-02-01
• DOI: 10.1128/aac.01349-12
• EISSN: 1098-6596
• ISSN: 0066-4804
• Language: English
• Keywords: Humans; Tanzania; Child, Preschool; Quinine; Malaria, Falciparum; Antimalarials; Child; Injections, Intramuscular; Infant; Plasmodium falciparum