Randomized comparison of intramuscular artemether and intravenous quinine in adult, Melanesian patients with severe or complicated, Plasmodium falciparum malaria in Papua New Guinea.

Journal article

An open-label, randomized, controlled trial was used to compare the safety and efficacy of intramuscular artemether (a loading dose of 3.2 mg/kg, followed by 1.6 mg/kg daily for 4 days) and intravenous quinine (a loading dose of 20 mg quinine dihydrochloride/kg, followed first by 10 mg/kg every 8 h, each injection taking 4 h, for at least 48 h, and then oral quinine for a total of 7 days) in the management of strictly defined severe/complicated malaria in Melanesian adults. Four (12%) of the ...

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Authors: Seaton, R; Trevett, A; Wembri, J; Nwokolo, N; Naraqi, S

• Publication status: Published
• Journal: Annals of tropical medicine and parasitology
• Volume: 92
• Issue: 2
• Pages: 133-139
• Publication date: 1998-03-01
• DOI: 10.1080/00034989859960
• EISSN: 1364-8594
• ISSN: 0003-4983
• Language: English
• Keywords: Humans; Antimalarials; Quinine; Adult; Papua New Guinea; Malaria, Falciparum; Artemisinins; Treatment Outcome; Injections, Intramuscular; Sesquiterpenes; Injections, Intravenous