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Beta-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis.

Abstract:

beta-catenin is involved in E-cadherin-mediated cell adhesion, intracellular signal transduction, and also interacts with adenomatous polyposis coli (APC) protein. We previously found that 31% of colorectal adenomas and 84% of carcinomas showed reduced membranous staining of beta-catenin, while 46% of adenomas and 79% of carcinomas displayed beta-catenin nuclear expression. Importantly, a reciprocal relationship between reduced membranous and increased nuclear beta-catenin expression was demo...

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Publisher copy:
10.1007/s00428-001-0570-0

Authors


Frayling, IM More by this author
Willcocks, TC More by this author
Tomlinson, IP More by this author
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Journal:
Virchows Archiv : an international journal of pathology
Volume:
440
Issue:
4
Pages:
362-366
Publication date:
2002-04-05
DOI:
EISSN:
1432-2307
ISSN:
0945-6317
URN:
uuid:08b8a47e-1f87-4b49-b83d-d58de8f94771
Source identifiers:
72201
Local pid:
pubs:72201

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