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Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension

Abstract:

Overproduction of nitric oxide (NO) is thought to be a key mediator of the vascular dysfunction and severe hypotension in patients with endotoxaemia and septic shock. The contribution of NO produced directly in the vasculature by endothelial cells to the hypotension seen in these conditions, vs. the broader systemic increase in NO, is unclear. To determine the specific role of endothelium derived NO in lipopolysaccharide (LPS)-induced vascular dysfunction we administered LPS to mice deficient...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More from this funder
Name:
National Institute for Health Research Oxford Biomedical Research Centre
Publisher:
Elsevier
Journal:
Vascular Pharmacology More from this journal
Volume:
77
Pages:
69-79
Publication date:
2015-08-11
DOI:
EISSN:
1879-3649
ISSN:
1537-1891
Language:
English
Keywords:
Pubs id:
pubs:539435
UUID:
uuid:08b77a19-1350-4b05-a46a-b55110e7a555
Local pid:
pubs:539435
Source identifiers:
539435
Deposit date:
2015-10-13

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