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Effect of 443c81, an inhaled mu-opioid receptor agonist in asthma.

Abstract:

Stimulation of exposed C-fibre afferent nerve endings by inflammatory mediators may contribute to airway inflammation and bronchoconstriction in asthma through the release of neuropeptides from collateral nerve endings. The polar opioid peptide 443c81 is a mu-opioid receptor agonist which inhibits C-fibre activation and non-cholinergic neurally mediated bronchoconstriction in animal models. We have compared the effect of 443c81 (5 ml of a 4 mg/ml solution nebulized) four times daily for 7 day...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Journal:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Volume:
24
Issue:
2
Pages:
144-148
Publication date:
1994-02-01
DOI:
EISSN:
1365-2222
ISSN:
0954-7894
Language:
English
Keywords:
Pubs id:
pubs:435411
UUID:
uuid:08b53885-d531-48a5-8167-f6e4845ce6fc
Local pid:
pubs:435411
Source identifiers:
435411
Deposit date:
2013-11-16

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