Atovaquone/proguanil: a review of its use for the prophylaxis of Plasmodium falciparum malaria.

Journal article

UNLABELLED: Atovaquone/proguanil is a fixed-dose combination tablet of two antimalarial agents and is highly effective for the prevention of Plasmodium falciparum malaria. In combination with proguanil, the ability of atovaquone to inhibit parasitic mitochondrial electron transport is markedly enhanced. Both atovaquone and proguanil are active against hepatic (pre-erythrocytic) stages of P. falciparum, thereby providing causal prophylaxis and eliminating the need to continue post-travel trea...

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Authors: McKeage, K; Scott, L

• Journal: Drugs
• Volume: 63
• Issue: 6
• Pages: 597-623
• Publication date: 2003-01-01
• DOI: 10.2165/00003495-200363060-00006
• ISSN: 0012-6667
• Language: English
• Keywords: Clinical Trials as Topic; Antimalarials; Dose-Response Relationship, Drug; Atovaquone; Humans; Drug Combinations; Naphthoquinones; Animals; Travel; Malaria, Falciparum; Proguanil