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Journal article

Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.

Abstract:

Mice deficient in c-fms-like tyrosine kinase 3 (FLT3) signaling have reductions in early multipotent and lymphoid progenitors, whereas no evident myeloid phenotype has been reported. However, activating mutations of Flt3 are among the most common genetic events in acute myeloid leukemia and mice harboring internal tandem duplications within Flt3 (Flt3-ITD) develop myeloproliferative disease, with characteristic expansion of granulocyte-monocyte (GM) progenitors (GMP), possibly compatible with...

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Publication status:
Published

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Journal:
Blood More from this journal
Volume:
115
Issue:
24
Pages:
5061-5068
Publication date:
2010-06-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Language:
English
Keywords:
Pubs id:
pubs:246611
UUID:
uuid:08abcb4d-3d1a-4e52-b11e-c2bcb602c654
Local pid:
pubs:246611
Source identifiers:
246611
Deposit date:
2012-12-19

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