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Pyocyanin degradation by a tautomerizing demethylase inhibits Pseudomonas aeruginosa biofilms

Abstract:

The opportunistic pathogen Pseudomonas aeruginosa produces colorful redox-active metabolites called phenazines, which underpin biofilm development, virulence and clinical outcomes. Though phenazines exist in many forms, the best studied is pyocyanin. Here, we describe pyocyanin demethylase (PodA), a hitherto uncharacterized protein that oxidizes the pyocyanin methyl group to formaldehyde and reduces the pyrazine ring via an unusual tautomerizing demethylation reaction. Treatment with PodA dis...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/science.aag3180

Authors


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Institution:
University of Oxford
Oxford college:
St Hugh's College
Role:
Author
More from this funder
Name:
National Science Foundation
Funding agency for:
Glasser, N
Grant:
1144469
More from this funder
Name:
National Institutes of Health
Funding agency for:
Costa, K
Grant:
F32AI112248
5R01HL117328-03
More from this funder
Name:
Gordon and Betty Moore Foundation
More from this funder
Name:
Molecular Observatory at the Beckman Institute
Publisher:
American Association for the Advancement of Science
Journal:
Science More from this journal
Volume:
355
Issue:
6321
Pages:
170-173
Publication date:
2017-01-13
Acceptance date:
2016-11-29
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Language:
English
Keywords:
Pubs id:
pubs:666470
UUID:
uuid:08ab931e-2dd1-4263-bb4b-1a8dfa5a8e71
Local pid:
pubs:666470
Source identifiers:
666470
Deposit date:
2016-12-19

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