Low level viral persistence after infection with LCMV: a quantitative insight through numerical bifurcation analysis.

Journal article

Many important viruses persist at very low levels in the body in the face of host immunity, and may influence the maintenance of this state of 'infection immunity'. To analyse low level viral persistence in quantitative terms, we use a mathematical model of antiviral cytotoxic T lymphocyte (CTL) response to lymphocytic choriomeningitis virus (LCMV). This model, described by a non-linear system of delay differential equations (DDEs), is studied using numerical bifurcation analysis techniques f...

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Authors: Luzyanina, T; Engelborghs, K; Ehl, S; Klenerman, P; Bocharov, G

• Publication status: Published
• Journal: Mathematical biosciences
• Volume: 173
• Issue: 1
• Pages: 1-23
• Publication date: 2001-09-01
• DOI: 10.1016/s0025-5564(01)00072-4
• EISSN: 1879-3134
• ISSN: 0025-5564
• Language: English
• Keywords: Immunologic Memory; Lymphocytic choriomeningitis virus; Lymphocytic Choriomeningitis; Mice; Models, Immunological; T-Lymphocytes, Cytotoxic; Viral Load; Animals