Journal article icon

Journal article

Overexpression of DNA polymerase beta results in an increased rate of frameshift mutations during base excision repair.

Abstract:

DNA polymerase beta (Pol beta) is important for the base excision repair (BER) pathway. Overexpression of Pol beta is frequently found in cancer cells and is thought to be associated with tumorigenesis. In this study, we examined BER fidelity in extracts derived from a human lymphoblastoid cell line that over expresses Pol beta compared to normal control cells. Using an in vitro mutagenesis assay, we found an increased rate of frameshift mutations arising during DNA repair in whole-cell extra...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/mutage/gel070

Authors


Houlbrook, S More by this author
Harrison, M More by this author
Hickson, ID More by this author
Expand authors...
Journal:
Mutagenesis
Volume:
22
Issue:
3
Pages:
183-188
Publication date:
2007-05-05
DOI:
EISSN:
1464-3804
ISSN:
0267-8357
URN:
uuid:08a82dc5-7f73-4192-8941-bdbcec5098d2
Source identifiers:
131335
Local pid:
pubs:131335

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP