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Overexpression of DNA polymerase beta results in an increased rate of frameshift mutations during base excision repair.

Abstract:

DNA polymerase beta (Pol beta) is important for the base excision repair (BER) pathway. Overexpression of Pol beta is frequently found in cancer cells and is thought to be associated with tumorigenesis. In this study, we examined BER fidelity in extracts derived from a human lymphoblastoid cell line that over expresses Pol beta compared to normal control cells. Using an in vitro mutagenesis assay, we found an increased rate of frameshift mutations arising during DNA repair in whole-cell extra...

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Publication status:
Published

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Publisher copy:
10.1093/mutage/gel070

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Journal:
Mutagenesis
Volume:
22
Issue:
3
Pages:
183-188
Publication date:
2007-05-01
DOI:
EISSN:
1464-3804
ISSN:
0267-8357
Source identifiers:
131335
Language:
English
Keywords:
Pubs id:
pubs:131335
UUID:
uuid:08a82dc5-7f73-4192-8941-bdbcec5098d2
Local pid:
pubs:131335
Deposit date:
2012-12-19

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