Journal article icon

Journal article

Effect of sildenafil and acclimatization on cerebral oxygenation at altitude.

Abstract:

Phosphodiesterase-5 inhibitors decrease hypoxic pulmonary vasoconstriction under hypobaric hypoxia, but are not known to affect cerebral blood flow or oxygenation. The present study was designed to evaluate the effect of sildenafil on cerebral haemodynamics during acute exposure to altitude and after acclimatization. Ten subjects were studied 1 and 3 days after rapid ascent to 3480 m before and for two consecutive hours after taking sildenafil (50 mg). Before acclimatization, HR (heart rate) ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1042/cs20050036

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Clinical science (London, England : 1979) More from this journal
Volume:
109
Issue:
3
Pages:
319-324
Publication date:
2005-09-01
DOI:
EISSN:
1470-8736
ISSN:
0143-5221
Language:
English
Keywords:
Pubs id:
pubs:241057
UUID:
uuid:08a7a82d-857d-451c-bcb9-52fa63615f9e
Local pid:
pubs:241057
Source identifiers:
241057
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP