Journal article

ESI-MS assay of M. tuberculosis cell wall antigen 85 enzymes permits substrate profiling and design of a mechanism-based inhibitor.

Abstract:: Mycobacterium tuberculosis Antigen 85 enzymes are vital to the integrity of the highly impermeable cell envelope and are potential therapeutic targets. Kinetic analysis using a label-free assay revealed both mechanistic details and a substrate profile that allowed the design and construction of a selective in vitro mechanism-based inhibitor.

Publication status:: Published

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Share
Cite

Cite this record

APA Style

Barry, C., Backus, K., Barry, C., & Davis, B. (2011). ESI-MS assay of M. tuberculosis cell wall antigen 85 enzymes permits substrate profiling and design of a mechanism-based inhibitor. Journal of the American Chemical Society, 133(34), 13232–13235.

MLA Style

Barry, C, et al. “ESI-MS Assay of M. Tuberculosis Cell Wall Antigen 85 Enzymes Permits Substrate Profiling and Design of a Mechanism-Based Inhibitor.” Journal of the American Chemical Society, vol. 133, no. 34, 2011, pp. 13232–35.

Chicago Style

Barry, C, K Backus, C Barry, and B Davis. 2011. “ESI-MS Assay of M. Tuberculosis Cell Wall Antigen 85 Enzymes Permits Substrate Profiling and Design of a Mechanism-Based Inhibitor.” Journal of the American Chemical Society 133 (34): 13232–35.
Print

Access Document

Publisher copy:: 10.1021/ja204249p

Authors

+ Barry, C More by this author

Role:: Author

+ Backus, K More by this author

Role:: Author

+ Barry, C More by this author

Role:: Author

+ Davis, B More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

Journal:: Journal of the American Chemical Society More from this journal
Volume:: 133
Issue:: 34
Pages:: 13232-13235
Publication date:: 2011-08-01
DOI:: 10.1021/ja204249p
EISSN:: 1520-5126
ISSN:: 0002-7863

Language:: English
Keywords:: Drug Design

Antigens, Bacterial

Tuberculosis

Bacterial Proteins

Mycobacterium tuberculosis

Antitubercular Agents

Humans

Spectrometry, Mass, Electrospray Ionization

Models, Molecular

Acyltransferases
Pubs id:: pubs:170129
UUID:: uuid:08a420eb-4202-4bdd-acc2-496c8301c55a
Local pid:: pubs:170129
Source identifiers:: 170129
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_08a420eb42024bddacc2496c8301c55a

Terms of use

Copyright date:: 2011

Licence:: Terms and Conditions of Use for Oxford University Research Archive

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP