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ESI-MS assay of M. tuberculosis cell wall antigen 85 enzymes permits substrate profiling and design of a mechanism-based inhibitor.

Abstract:
Mycobacterium tuberculosis Antigen 85 enzymes are vital to the integrity of the highly impermeable cell envelope and are potential therapeutic targets. Kinetic analysis using a label-free assay revealed both mechanistic details and a substrate profile that allowed the design and construction of a selective in vitro mechanism-based inhibitor.
Publication status:
Published

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Publisher copy:
10.1021/ja204249p

Authors


Backus, KM More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Journal of the American Chemical Society
Volume:
133
Issue:
34
Pages:
13232-13235
Publication date:
2011-08-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:08a420eb-4202-4bdd-acc2-496c8301c55a
Source identifiers:
170129
Local pid:
pubs:170129

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