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Selectivity and permeation of alkali metal ions in K +-channels

Abstract:

Ion conduction in K +-channels is usually described in terms of concerted movements of K + progressing in a single file through a narrow pore. Permeation is driven by an incoming ion knocking on those ions already inside the protein. A fine-tuned balance between high-affinity binding and electrostatic repulsive forces between permeant ions is needed to achieve efficient conduction. While K +-channels are known to be highl...

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Publisher copy:
10.1016/j.jmb.2011.04.043

Authors


Journal:
Journal of Molecular Biology
Volume:
409
Issue:
5
Pages:
867-878
Publication date:
2011-06-24
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:0896e38c-f59f-446f-b952-743f8e689867
Source identifiers:
162213
Local pid:
pubs:162213

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