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Cryo-electron tomography and 3-D analysis of the intact flagellum in Trypanosoma brucei

Abstract:

Trypanosoma brucei is a uni-cellular protist that causes African sleeping sickness. These parasites have a flagellum that is attached to the cell body and is indispensible for its motility. The flagellum consists of a canonical 9+2 axoneme and a paraflagellar rod (PFR), an intricate tripartite, fibrous structure that is connected to the axoneme. In this paper we describe results from cryo-electron tomography of unperturbed flagella. This method revealed novel structures that are likely involv...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jsb.2012.01.009

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Publisher:
Elsevier
Journal:
Journal of structural biology More from this journal
Volume:
178
Issue:
2
Pages:
189-198
Publication date:
2012-05-01
DOI:
EISSN:
1095-8657
ISSN:
1047-8477
Language:
English
Keywords:
Pubs id:
pubs:245879
UUID:
uuid:089477e7-3ed5-42b3-8ec7-977af31128ac
Local pid:
pubs:245879
Source identifiers:
245879
Deposit date:
2012-12-19

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