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Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice.

Abstract:

The roles played by the endogenous angiogenesis inhibitor thrombospondin-1 (TSP-1) in the early stages of multi-step carcinogenesis and in the control of hematogenous versus lymphatic metastasis are unknown. To investigate these issues we compared tumor development in normal mice and in transgenic mice with targeted overexpression of TSP-1 in the epidermis following a standard two-step chemical skin carcinogenesis regimen. Overexpression of TSP-1 resulted in delayed and reduced development of...

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Publication status:
Published

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Publisher copy:
10.1038/sj.onc.1205956

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Journal:
Oncogene
Volume:
21
Issue:
52
Pages:
7945-7956
Publication date:
2002-11-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:089110c3-2246-4f9a-910d-c59fd3631d80
Source identifiers:
102756
Local pid:
pubs:102756

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