Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes.

Journal article

The carboxy-terminal domain (CTD) of the large subunit of RNA polymerase II (Pol II) comprises multiple heptapeptide repeats of the consensus Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. Reversible phosphorylation of Ser2, Ser5, and Ser7 during the transcription cycle mediates the sequential recruitment of transcription/RNA processing factors. Phosphorylation of Ser7 is required for recruitment of the gene type-specific Integrator complex to the Pol II-transcribed small nuclear (sn)RNA genes. Here, we...

Expand abstract

Authors: Egloff, S; Zaborowska, J; Laitem, C; Kiss, T; Murphy, S

• Publication status: Published
• Journal: Molecular cell
• Volume: 45
• Issue: 1
• Pages: 111-122
• Publication date: 2012-01-01
• DOI: 10.1016/j.molcel.2011.11.006
• EISSN: 1097-4164
• ISSN: 1097-2765
• Language: English
• Keywords: Phosphorylation; Molecular Sequence Data; Humans; Protein Interaction Mapping; Carrier Proteins; RNA, Small Nuclear; Protein Structure, Tertiary; Transcription, Genetic; Serine; Amino Acid Sequence; RNA Polymerase II