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MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas.

Abstract:

The OX-TES-4 antigen originally elicited an antibody response in 50% of diffuse large B-cell lymphoma (DLBCL) patients but not in control subjects. OX-TES-4 is encoded by a novel gene, MORC4, located at chromosome Xq22.3. The MORC4 protein contains a HATPase-c domain, CW zinc finger motif, nuclear localisation signals and a nuclear matrix-binding domain, together with a coiled-coil region. MORC4 mRNA is widely expressed at low levels in normal tissues, showing highest expression levels in pla...

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Publication status:
Published

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Journal:
British journal of haematology
Volume:
138
Issue:
4
Pages:
479-486
Publication date:
2007-08-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:088b5ede-32de-448d-8c60-be4e6406c3a3
Source identifiers:
108213
Local pid:
pubs:108213

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