Diastolic dysfunction is not related to changes in glycaemic control over 6 months in type 2 (non-insulin-dependent) diabetes mellitus. A cross-sectional study.

Journal article

Diastolic dysfunction may be the earliest marker of a diabetes-induced heart muscle disease which leads to the progressive development of cardiac failure. Left ventricular diastolic function was indirectly assessed using pulsed wave Doppler ultrasound mitral-flow velocities in 20 normotensive patients with a new diagnosis of type 2 diabetes mellitus, normal cardiac function and no evidence of coronary artery disease and in 16 age-matched normal subjects. Peak velocities of early (E) and late (A) left ventricular filling were measured. The median (interquartile ranges) peak E/A ratio was significantly reduced in the diabetic group 0.96 (0.8-1.2) vs 1.2 (1.1-1.3), P < 0.01. Despite improvements in glycaemic control over 3 months, HbA1c 9.9% (7.6%-10.5%) to 7.4% (6.5%-7.9%), P < 0.001, maintained at 6 months, HbA1c 7.0% (6.4%-7.3%), there were no changes in the E/A ratio, 0.96 (0.83-1.15) and 0.95 (0.83-1.17), respectively. Furthermore, there was no correlation between percentage change in HbA1c and E/A ratio over 6 months. The results of this study suggest that in patients with type 2 diabetes mellitus and normal systolic function, diastolic function was impaired at diagnosis and was not affected by an improvement in the glycaemic control.

Authors: Gough, S; Smyllie, J; Barker, M; Berkin, K; Rice, P

• Publisher: Springer-Verlag
• Journal: Acta diabetologica
• Volume: 32
• Issue: 2
• Pages: 110-115
• Publication date: 1995-06-01
• DOI: 10.1007/bf00569568
• EISSN: 1432-5233
• ISSN: 0940-5429
• Language: English
• Keywords: Fibrinogen; Triglycerides; Glucose Tolerance Test; Diastole; Middle Aged; Systole; Electrocardiography; Gated Blood-Pool Imaging; Reference Values; Follow-Up Studies; Diabetes Mellitus, Type 2; Blood Glucose; Cholesterol; Humans; Time Factors; Hemoglobin A, Glycosylated; Ventricular Function, Left