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Journal article

Profibrogenic chemokines and viral evolution predict rapid progression of hepatitis C to cirrhosis.

Abstract:

Chronic hepatitis C may follow a mild and stable disease course or progress rapidly to cirrhosis and liver-related death. The mechanisms underlying the different rates of disease progression are unknown. Using serial, prospectively collected samples from cases of transfusion-associated hepatitis C, we identified outcome-specific features that predict long-term disease severity. Slowly progressing disease correlated with an early alanine aminotransferase peak and antibody seroconversion, trans...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1210592109

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
109
Issue:
36
Pages:
14562-14567
Publication date:
2012-09-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:0889b6d5-2068-4fa8-b674-fb6b29360abd
Source identifiers:
344128
Local pid:
pubs:344128

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