Journal article
ATM, ATR, and DNA-PK: The trinity at the heart of the DNA damage response
- Abstract:
- In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM, ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be identified. During this time, our understanding of how these kinases regulate DNA repair and associated events has grown profoundly, although major questions remain unanswered. Here, we provide a historical perspective of their discovery and discuss their established functions in sensing and responding to genotoxic stress. We also highlight what is known regarding their structural similarities and common mechanisms of regulation, as well as emerging non-canonical roles and how our knowledge of ATM, ATR, and DNA-PK is being translated to benefit human health.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Preview, Accepted manuscript, pdf, 2.5MB, Terms of use)
-
- Publisher copy:
- 10.1016/j.molcel.2017.05.015
Authors
+ Cancer Research UK
More from this funder
- Funding agency for:
- Blackford, A
- Grant:
- C29215/A20772
- C6946/A14492
- Publisher:
- Cell Press
- Journal:
- Molecular Cell More from this journal
- Volume:
- 66
- Issue:
- 6
- Pages:
- 801-817
- Publication date:
- 2017-06-15
- Acceptance date:
- 2017-05-16
- DOI:
- ISSN:
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1097-4164
- Language:
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English
- Pubs id:
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pubs:702140
- UUID:
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uuid:08865817-a929-480c-b0ab-8ce634ebaf16
- Local pid:
-
pubs:702140
- Source identifiers:
-
702140
- Deposit date:
-
2017-06-30
Terms of use
- Copyright holder:
- Elsevier Inc
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Elsevier Inc. This is the accepted manuscript version of the article. The final version is available online from Cell Press at: https://doi.org/10.1016/j.molcel.2017.05.015
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