Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns.

Journal article

OBJECTIVE: To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS). METHODS: A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed. RESULTS: In the Finnish study the CD14-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses. CONCLUSION: CD14 and TLR4 showed an association with AS in the Finns only.

Authors: Pointon, J; Chapman, K; Harvey, D; Sims, A; Bradbury, L

• Publication status: Published
• Journal: Journal of rheumatology
• Volume: 35
• Issue: 8
• Pages: 1609-1612
• Publication date: 2008-08-01
• ISSN: 0315-162X
• Language: English
• Keywords: Case-Control Studies; Antigens, CD14; Polymorphism, Single Nucleotide; Toll-Like Receptor 4; Cohort Studies; Finland; Male; Female; Great Britain; Humans; Odds Ratio; Spondylitis, Ankylosing; Genetic Predisposition to Disease