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Evolution of multidrug resistance in Plasmodium falciparum: A longitudinal study of genetic resistance markers in the Greater Mekong subregion

Abstract:

Increasing resistance in Plasmodium falciparum to artemisinins and their artemisinin combination therapy (ACT) partner drugs jeopardizes effective antimalarial treatment. Resistance is worst in the Greater Mekong subregion. Monitoring genetic markers of resistance can help to guide antimalarial therapy. Markers of resistance to artemisinins (PfKelch mutations), mefloquine (amplification of P. falciparum multidrug resistance-1 [PfMDR1]), and piperaquine (PfPlasmepsin2/3 amplification and speci...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/aac.01121-21

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
ORCID:
0000-0002-8770-0573
More by this author
Institution:
University of Oxford
Department:
External
Role:
Author
Publisher:
American Society for Microbiology
Journal:
Antimicrobial Agents and Chemotherapy More from this journal
Volume:
65
Issue:
12
Article number:
e01121-21
Publication date:
2021-11-17
Acceptance date:
2021-09-07
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pmid:
34516247
Language:
English
Keywords:
Pubs id:
1195303
Local pid:
pubs:1195303
Deposit date:
2021-12-21

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