Journal article
Evolution of multidrug resistance in Plasmodium falciparum: A longitudinal study of genetic resistance markers in the Greater Mekong subregion
- Abstract:
-
Increasing resistance in Plasmodium falciparum to artemisinins and their artemisinin combination therapy (ACT) partner drugs jeopardizes effective antimalarial treatment. Resistance is worst in the Greater Mekong subregion. Monitoring genetic markers of resistance can help to guide antimalarial therapy. Markers of resistance to artemisinins (PfKelch mutations), mefloquine (amplification of P. falciparum multidrug resistance-1 [PfMDR1]), and piperaquine (PfPlasmepsin2/3 amplification and speci...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- American Society for Microbiology Publisher's website
- Journal:
- Antimicrobial Agents and Chemotherapy Journal website
- Volume:
- 65
- Issue:
- 12
- Article number:
- e01121-21
- Publication date:
- 2021-11-17
- Acceptance date:
- 2021-09-07
- DOI:
- EISSN:
-
1098-6596
- ISSN:
-
0066-4804
- Pmid:
-
34516247
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1195303
- Local pid:
- pubs:1195303
- Deposit date:
- 2021-12-21
Terms of use
- Copyright holder:
- Imwong et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 Imwong et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
- Licence:
- CC Attribution (CC BY)
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