Hypoxia and angiogenesis in rheumatoid arthritis.

Journal article

PURPOSE OF REVIEW: Angiogenesis is a prominent feature of rheumatoid synovitis. Although new blood vessels deliver oxygen to the augmented inflammatory cell mass, the neovascular network is dysfunctional and fails to restore tissue oxygen homeostasis, so that the rheumatoid joint remains a markedly hypoxic environment. The purpose of this review is to discuss the role of hypoxia and angiogenesis in the pathogenesis of rheumatoid arthritis. RECENT FINDINGS: Vascular pathologic change, in the ...

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Authors: Taylor, P; Sivakumar, B

• Publication status: Published
• Journal: Current opinion in rheumatology
• Volume: 17
• Issue: 3
• Pages: 293-298
• Publication date: 2005-05-01
• DOI: 10.1097/01.bor.0000155361.83990.5b
• EISSN: 1531-6963
• ISSN: 1040-8711
• Language: English
• Keywords: Transcription Factors; Vascular Endothelial Growth Factor A; Neovascularization, Pathologic; Synovial Membrane; Anoxia; Endothelium, Vascular; Nuclear Proteins; Humans; Hypoxia-Inducible Factor 1; Disease Progression; Arthritis, Rheumatoid; Hypoxia-Inducible Factor 1, alpha Subunit; DNA-Binding Proteins