Journal article icon

Journal article

Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations.

Abstract:

Glucokinase (GCK) is a key regulatory enzyme in the pancreatic beta-cell and catalyzes the rate-limiting step for beta-cell glucose metabolism. We report two novel GCK mutations (T65I and W99R) that have arisen de novo in two families with familial hypoglycemia. Insulin levels, although inappropriately high for the degree of hypoglycemia, remain regulated by fluctuations in glycemia, and pancreatic histology was normal. These mutations are within the recently identified heterotropic allosteri...

Expand abstract

Actions


Access Document


Publisher copy:
10.2337/diabetes.52.9.2433

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Noordam, K More by this author
Willemsen, MA More by this author
Expand authors...
Journal:
Diabetes
Volume:
52
Issue:
9
Pages:
2433-2440
Publication date:
2003-09-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:087e91c1-5df4-42cd-b701-002230007d00
Source identifiers:
26948
Local pid:
pubs:26948

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP