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Journal article

Effect on adherence to nicotine replacement therapy of informing smokers their dose is determined by their genotype: a randomised controlled trial.

Abstract:

BACKGROUND: The behavioural impact of pharmacogenomics is untested. We tested two hypotheses concerning the behavioural impact of informing smokers their oral dose of NRT is tailored to analysis of DNA.

METHODS AND FINDINGS: We conducted an RCT with smokers in smoking cessation clinics (N = 633). In combination with NRT patch, participants were informed that their doses of oral NRT were based either on their mu-opioid receptor (OPRM1) genotype, or their nicotine dependence questionn...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Department:
National Institute for Health Research; UK centre for Tobacco Control Studies
Role:
Author
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British Heart Foundation More from this funder
Cancer Research UK More from this funder
Economic and Social Research Council More from this funder
National Institute for Health Research More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
7
Issue:
4
Pages:
e35249
Publication date:
2012-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
325755

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