Journal article
AMP-activated protein kinase couples mitochondrial inhibition by hypoxia to cell-specific Ca2+ signalling mechanisms in oxygen-sensing cells.
- Abstract:
-
It is generally accepted that relatively mild hypoxia inhibits mitochondrial oxidative phosphorylation in O2-sensing cells, and thereby mediates, in part, cell activation. However, the mechanism by which this process is coupled to discrete, cell-specific Ca2+ signalling mechanisms remains elusive. We considered the possibility that hypoxia may increase the cellular ATP/AMP ratio, increase the activity of AMP-activated protein kinase (AMPK) and thereby evoke Ca2+ signals in O2-sensing cells. C...
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Bibliographic Details
- Journal:
- Novartis Foundation symposium
- Volume:
- 272
- Pages:
- 234-279
- Publication date:
- 2006-01-01
- EISSN:
-
1935-4657
- ISSN:
-
1528-2511
- Source identifiers:
-
106390
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:106390
- UUID:
-
uuid:087a886f-df06-4929-a3ae-f08e3158e1cb
- Local pid:
- pubs:106390
- Deposit date:
- 2013-02-20
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- Copyright date:
- 2006
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