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AMP-activated protein kinase couples mitochondrial inhibition by hypoxia to cell-specific Ca2+ signalling mechanisms in oxygen-sensing cells.

Abstract:

It is generally accepted that relatively mild hypoxia inhibits mitochondrial oxidative phosphorylation in O2-sensing cells, and thereby mediates, in part, cell activation. However, the mechanism by which this process is coupled to discrete, cell-specific Ca2+ signalling mechanisms remains elusive. We considered the possibility that hypoxia may increase the cellular ATP/AMP ratio, increase the activity of AMP-activated protein kinase (AMPK) and thereby evoke Ca2+ signals in O2-sensing cells. C...

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Authors


Hardie, DG More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
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Journal:
Novartis Foundation symposium
Volume:
272
Pages:
234-279
Publication date:
2006
EISSN:
1935-4657
ISSN:
1528-2511
URN:
uuid:087a886f-df06-4929-a3ae-f08e3158e1cb
Source identifiers:
106390
Local pid:
pubs:106390

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