Journal article
Trichomonas vaginalis and HIV infection acquisition: a systematic review and meta-analysis
- Abstract:
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Objectives Trichomoniasis is the most prevalent curable STI globally, with the highest incidence and prevalence in sub-Saharan Africa (sSA). STIs have largely been associated with an increase in HIV acquisition. Our objective was to assess the existing literature available in English regarding the association of Trichomoniasis and HIV-1 acquisition.
Methods The review protocol was registered at the International Prospective Register of Systematic Reviews (PROSPERO) under number CRD42018082702. We searched MEDLINE, Embase and Scopus databases to collect articles measuring the association of Trichomonas vaginalis infection and HIV acquisition and performed a meta-analysis and qualitative synthesis of the literature.
Results We identified 1806 unduplicated citations, of which 18 papers and 1 conference abstract were eligible for inclusion in the review after applying our inclusion and exclusion criteria. All the studies included in the systematic review had been carried out in sSA. The articles reported various measures of effects, namely: HRs, rate ratios, risk ratios and ORs. In a meta-analysis restricted to 11 studies reporting HR, individuals infected with T. vaginalis were 1.5 times more likely to acquire HIV compared with individuals not infected with T. vaginalis (95% CI 1.3 to 1.7; p<0.001).
Conclusions T. vaginalis is an important factor in HIV acquisition especially in sSA where the prevalence of both T. vaginalis and HIV-1 are high. This systematic review and meta-analysis confirms the evidence that infection with T. vaginalis augments HIV acquisition with 50%. Diagnosis and treatment of T. vaginalis infection in both high-risk and low-risk individuals may be a potential tool to reduce new HIV infections.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1020.3KB, Terms of use)
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- Publisher copy:
- 10.1136/sextrans-2018-053713
Authors
- Publisher:
- BMJ Publishing Group
- Journal:
- Sexually transmitted infections More from this journal
- Volume:
- 95
- Issue:
- 1
- Publication date:
- 2018-10-19
- Acceptance date:
- 2018-09-18
- DOI:
- EISSN:
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1472-3263
- ISSN:
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1368-4973
- Pmid:
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30341233
- Language:
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English
- Keywords:
- Pubs id:
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pubs:936565
- UUID:
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uuid:0873a21a-2de9-4ca0-95e1-f0e5a16725f4
- Local pid:
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pubs:936565
- Source identifiers:
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936565
- Deposit date:
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2019-01-21
Terms of use
- Copyright holder:
- Masha et al
- Copyright date:
- 2018
- Notes:
- © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0
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