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Whole-genome linkage scan combined with exome sequencing identifies novel candidate genes for carotid intima-media thickness

Abstract:

Carotid intima-media thickness (cIMT) is an established heritable marker for subclinical atherosclerosis. In this study, we aim to identify rare variants with large effects driving differences in cIMT by performing genome-wide linkage analysis of individuals in the extremes of cIMT trait distribution (>90th percentile) in a large family-based study from a genetically isolated population in the Netherlands. Linked regions were subsequently explored by fine-mapping using exome sequencing. We...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Name:
Seventh Framework Programme
Grant:
HEALTH-F4-2007-201413
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Name:
Sixth Framework Programme
Grant:
018947 (LSHG-CT-2006-01947
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Name:
Fifth Framework Programme
Grant:
QLG2-CT-2002-01254
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Name:
Netherlands Brain Foundation Project
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Name:
Biobanking and Biomolecular Research Infrastructure Netherlands
Publisher:
Frontiers Media
Journal:
Frontiers in Genetics More from this journal
Volume:
9
Issue:
OCT
Pages:
420
Publication date:
2018-10-09
Acceptance date:
2018-09-10
DOI:
EISSN:
1664-8021
Pmid:
30356672
Language:
English
Keywords:
Pubs id:
pubs:929717
UUID:
uuid:086db45c-e879-4451-a876-e7961097dd12
Local pid:
pubs:929717
Source identifiers:
929717
Deposit date:
2018-11-21

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