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Antibody to aquaporin-4 in the long-term course of neuromyelitis optica

Abstract:

Neuromyelitis optica (NMO) is a severe inflammatory CNS disorder of putative autoimmune aetiology, which predominantly affects the spinal cord and optic nerves. Recently, a highly specific serum reactivity to CNS microvessels, subpia and Virchow-Robin spaces was described in patients with NMO [called NMO-IgG (NMO-immunoglobulin G)]. Subsequently, aquaporin-4 (AQP4), the most abundant water channel in the CNS, was identified as its target antigen. Strong support for a pathogenic role of the an...

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Publisher copy:
10.1093/brain/awn240

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Brain More from this journal
Volume:
131
Issue:
11
Pages:
3072-3080
Publication date:
2008-11-01
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Language:
English
Keywords:
Pubs id:
pubs:243386
UUID:
uuid:086cc6f9-ee02-4fa0-86f1-5305ccc5a130
Local pid:
pubs:243386
Source identifiers:
243386
Deposit date:
2012-12-19

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