Journal article
A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells
- Abstract:
- Insulin secretion depends on action potential firing in pancreatic islet beta-cells, but the underlying mechanism is unclear. Here, the authors show that activation of the mechanosensor ion channel PIEZO1 plays a central role in beta-cell electrical activity and insulin release
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.9MB, Terms of use)
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- Publisher copy:
- 10.1038/s41467-022-31103-y
- Publication website:
- https://www.nature.com/articles/s41467-022-31103-y.pdf
Authors
+ Lund University | Medicinska Fakulteten, Lunds Universitet
More from this funder
- Funder identifier:
- 10.13039/501100006738
- Grant:
- ALF ER
- Publisher:
- Nature Research
- Journal:
- Nature Communications More from this journal
- Volume:
- 13
- Issue:
- 1
- Pages:
- 4237-4237
- Article number:
- 4237
- Publication date:
- 2022-07-22
- DOI:
- EISSN:
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2041-1723
- ISSN:
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2041-1723
- Language:
-
English
- Keywords:
- Pubs id:
-
1269946
- Local pid:
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pubs:1269946
- Source identifiers:
-
W4286487966
- Deposit date:
-
2026-04-27
- ARK identifier:
This ORA record was generated from metadata provided by an external service. It has not been edited by the ORA Team.
Terms of use
- Copyright date:
- 2022
- Licence:
- CC Attribution (CC BY)
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