Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice.

Journal article

Significant differences in colon cancer incidence worldwide have led to the hypothesis that this variation can be explained largely by environmental, notably dietary influences. Although a positive correlation between dietary fat intake and incidence is suggested from some human epidemiological and rodent carcinogenesis studies, a direct association remains contentious. Using a spontaneous mouse tumor model of multiple intestinal neoplasia, we demonstrate that there is a generalized increase ...

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Authors: Wasan, H; Novelli, M; Bee, J; Bodmer, W

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 94
• Issue: 7
• Pages: 3308-3313
• Publication date: 1997-04-01
• DOI: 10.1073/pnas.94.7.3308
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Intestinal Neoplasms; Neoplasms, Multiple Primary; Mice, Inbred C57BL; Female; Animals; Intestinal Polyps; Dietary Fats; Phenotype; Mice; Colon; Intestine, Small; Mammary Neoplasms, Experimental