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Rct1, a nuclear RNA recognition motif-containing cyclophilin, regulates phosphorylation of the RNA polymerase II C-terminal domain.

Abstract:

Phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (RNAP II) is a dynamic process that regulates transcription and coordinates it with pre-mRNA processing. We show here that Rct1, a nuclear multidomain cyclophilin from Schizosaccharomyces pombe, is encoded by an essential gene that interacts with the CTD and regulates its phosphorylation in vivo. Downregulation of Rct1 levels results in increased phosphorylation of the CTD at both Ser2 and Ser5 and in a commensurate decrease ...

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Publication status:
Published

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Publisher copy:
10.1128/mcb.02187-06

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Molecular and cellular biology More from this journal
Volume:
27
Issue:
10
Pages:
3601-3611
Publication date:
2007-05-01
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
Language:
English
Keywords:
Pubs id:
pubs:55332
UUID:
uuid:085e99e2-737f-4b73-9a11-dce6ce01ca99
Local pid:
pubs:55332
Source identifiers:
55332
Deposit date:
2012-12-19

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