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Vaccination with a modified vaccinia virus Ankara (MVA)-vectored HIV-1 immunogen induces modest vector-specific T cell responses in human subjects.

Abstract:

We investigated whether vaccination of healthy HIV-seronegative and HIV-1-seropositive antiretroviral therapy-treated subjects with recombinant modified vaccinia virus Ankara expressing an HIV-1 immunogen (MVA.HIVA) induced MVA-specific T cell responses. Using IFN-γ Elispot assays, we observed new or increased responses to MVA virus in 52% of HIV-seronegative subjects and 93% HIV-1 seropositive subjects; MVA-specific T cell frequencies were generally low and correlated poorly with T cell resp...

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Publication status:
Published

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Journal:
Vaccine More from this journal
Volume:
28
Issue:
45
Pages:
7306-7312
Publication date:
2010-10-01
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
Language:
English
Keywords:
Pubs id:
pubs:71160
UUID:
uuid:085744af-72b2-4612-95ff-bf940301737f
Local pid:
pubs:71160
Source identifiers:
71160
Deposit date:
2012-12-19

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