Autophagy is crucial during tissue development, as the developing cell has to constantly adapt to cell-intrinsic and environmental changes. For instance, protein aggregates need to be cleared, superfluous organelles removed and cell shape adapted to the new function of the cell. One typical example of such a developmental adaptation is that of the red blood cell (RBC). In order to reach the smallest capillaries, the RBC has to reduce its size considerably and the nucleus is expelled from the ...Expand abstract
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Nonredundant role of Atg7 in mitochondrial clearance during erythroid development.
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