Pregnancy and infant outcomes among HIV-infected women taking long-term ART with and without tenofovir in the DART trial.

Journal article

BACKGROUND: Few data have described long-term outcomes for infants born to HIV-infected African women taking antiretroviral therapy (ART) in pregnancy. This is particularly true for World Health Organization (WHO)-recommended tenofovir-containing first-line regimens, which are increasingly used and known to cause renal and bone toxicities; concerns have been raised about potential toxicity in babies due to in utero tenofovir exposure. METHODS AND FINDINGS: Pregnancy outcome and maternal/infan...

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Authors: Gibb, D; Kizito, H; Russell, E; Chidziva, E; Zalwango, E

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Public Library of Science
• Journal: PLoS medicine
• Volume: 9
• Issue: 5
• Article number: e1001217
• Publication date: 2012-01-01
• DOI: 10.1371/journal.pmed.1001217
• EISSN: 1549-1676
• ISSN: 1549-1277
• Language: English
• Keywords: Body Weight; Breast Feeding; Drug Combinations; Infant; Respiratory Tract Infections; Anti-HIV Agents; Adenine; Pregnancy Outcome; Fractures, Bone; Humans; Organophosphonates; Male; Lamivudine; DART trial team; Abortion, Spontaneous; Congenital Abnormalities; Growth; Follow-Up Studies; Infant, Newborn; Cause of Death; Pregnancy; Infant Mortality; HIV Seropositivity; Measles; Female; Zimbabwe; Uganda; HIV Infections; Prevalence; Burns; Zidovudine; Adult; Infectious Disease Transmission, Vertical; Body Height; Pregnancy Complications, Infectious; Child, Preschool