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Assessment of F/HN-pseudotyped lentivirus as a clinically relevant vector for lung gene therapy.

Abstract:

RATIONALE: Ongoing efforts to improve pulmonary gene transfer thereby enabling gene therapy for the treatment of lung diseases, such as cystic fibrosis (CF), has led to the assessment of a lentiviral vector (simian immunodeficiency virus [SIV]) pseudotyped with the Sendai virus envelope proteins F and HN. OBJECTIVES: To place this vector onto a translational pathway to the clinic by addressing some key milestones that have to be achieved. METHODS: F/HN-SIV transduction efficiency, duration of...

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Publication status:
Published

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Publisher copy:
10.1164/rccm.201206-1056oc

Authors


Griesenbach, U More by this author
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Journal:
American journal of respiratory and critical care medicine
Volume:
186
Issue:
9
Pages:
846-856
Publication date:
2012-11-05
DOI:
EISSN:
1535-4970
ISSN:
1073-449X
URN:
uuid:0844e52f-bf7b-4e7d-a7c6-239eb7d604bf
Source identifiers:
359941
Local pid:
pubs:359941

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