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Visually driven regulation of intrinsic neuronal excitability improves stimulus detection in vivo.

Abstract:

Neurons adapt their electrophysiological properties to maintain stable levels of electrical excitability when faced with a constantly changing environment. We find that exposing freely swimming Xenopus tadpoles to 4-5 hr of persistent visual stimulation increases the intrinsic excitability of optic tectal neurons. This increase is correlated with enhanced voltage-gated Na+ currents. The same visual stimulation protocol also induces a polyamine synthesis-dependent reduction in Ca2+-permeable A...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Neuron
Volume:
39
Issue:
5
Pages:
831-842
Publication date:
2003-08-01
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
Source identifiers:
185313
Language:
English
Keywords:
Pubs id:
pubs:185313
UUID:
uuid:083f18a3-5183-48d8-8a6d-36542e7ccfd6
Local pid:
pubs:185313
Deposit date:
2012-12-19

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