Prolonged half-life of verapamil in a case of overdose: implications for therapy.
After an overdose of verapamil (2.4 g) in a 59-year-old man the apparent half-life of verapamil was prolonged (15 h). The most likely mechanism is rate-limiting absorption, although changes in clearance and volume of distribution may contribute. As the elimination half-life of verapamil is increased in overdose, therapy may have to be continued for longer than expected. Moreover since the half-life of absorption of verapamil in overdose may be prolonged, activated charcoal should be given in ...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
If you are the owner of this record, you can report an update to it here: Report update to this record