- Abstract:
-
After an overdose of verapamil (2.4 g) in a 59-year-old man the apparent half-life of verapamil was prolonged (15 h). The most likely mechanism is rate-limiting absorption, although changes in clearance and volume of distribution may contribute. As the elimination half-life of verapamil is increased in overdose, therapy may have to be continued for longer than expected. Moreover since the half-life of absorption of verapamil in overdose may be prolonged, activated charcoal should be given in ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/j.1365-2125.1995.tb05729.x
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- Journal:
- British journal of clinical pharmacology
- Volume:
- 39
- Issue:
- 6
- Pages:
- 680-683
- Publication date:
- 1995-06-05
- DOI:
- EISSN:
-
1365-2125
- ISSN:
-
0306-5251
- URN:
-
uuid:083cd13f-ed91-413b-a478-ccff19dda3ac
- Source identifiers:
-
322068
- Local pid:
- pubs:322068
- Copyright date:
- 1995
Journal article
Prolonged half-life of verapamil in a case of overdose: implications for therapy.
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