Arthroplasty membrane-derived fibroblasts directly induce osteoclast formation and osteolysis in aseptic loosening.

Journal article

PURPOSE: Both macrophages and fibroblasts are the main cell types found in periprosthetic tissues surrounding failed joint arthroplasties. These fibroblasts are known to express RANKL and to produce TNFalpha, factors which promote osteoclast formation and bone resorption. In this study we have analysed the role that arthroplasty membrane-derived fibroblasts (AFb) play in inducing the generation of bone resorbing osteoclasts. METHODS: Fibroblasts were isolated from periprosthetic tissues and c...

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Authors: Sabokbar, A; Itonaga, I; Sun, S; Kudo, O; Athanasou, N

• Publication status: Published
• Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society
• Volume: 23
• Issue: 3
• Pages: 511-519
• Publication date: 2005-05-01
• DOI: 10.1016/j.orthres.2004.10.006
• EISSN: 1554-527X
• ISSN: 0736-0266
• Language: English
• Keywords: Osteoclasts; Osteoprotegerin; Fibroblasts; Glycoproteins; Arthroplasty; Male; Tumor Necrosis Factor-alpha; RANK Ligand; Humans; Aged, 80 and over; Osteolysis; Middle Aged; Receptor Activator of Nuclear Factor-kappa B; Receptors, Tumor Necrosis Factor; Carrier Proteins; Receptors, Cytoplasmic and Nuclear; Aged; Female; Membrane Glycoproteins