Clinically relevant thresholds for ultrasensitive HIV drug resistance testing: a multi-country nested case-control study
BackgroundImplementation of ultrasensitive HIV drug resistance tests for routine clinical use is hampered by uncertainty about the clinical relevance of drug-resistant minority variants. We assessed different detection thresholds for pretreatment drug resistance to predict an increased risk of virological failure.
MethodsWe did a case-control study nested within a prospective multicountry cohort. Our study included patients from 12 clinical sites in Kenya, Nigeri... Expand abstract
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