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Identification of a novel muscle targeting peptide in mdx mice.

Abstract:

Exon-skipping oligonucleotides are a well-researched therapeutic strategy for Duchenne's muscular dystrophy (DMD). Despite remarkable successes in animal models with intramuscular and intravenous delivery of unmodified oligonucleotides, the ability to specifically target both normal and dystrophic muscle with a simple peptide ligand could decrease the therapeutic dose required and reduce the potential for toxicity. Thus, 3 rounds of in vivo phage display utilizing a 12-mer peptide library wer...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Peptides
Volume:
31
Issue:
10
Pages:
1873-1877
Publication date:
2010-10-01
DOI:
EISSN:
1873-5169
ISSN:
0196-9781
Source identifiers:
114170
Language:
English
Keywords:
Pubs id:
pubs:114170
UUID:
uuid:08375ece-901d-4c9a-b3f5-d2fefceb3489
Local pid:
pubs:114170
Deposit date:
2013-09-17

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