Temporal analysis of early immune responses in patients with acute hepatitis B virus infection.

Journal article

BACKGROUND and AIMS: Hepatitis B virus (HBV) causes more than 1 million deaths annually from immune-mediated liver damage. The long incubation period has been difficult to study; by the time most patients present, massive viremia and the majority of viral clearance have already occurred. The aim of this study was to investigate the contribution of innate and adaptive immune mechanisms in early acute HBV through access to an unusual cohort of patients sampled in the preclinical phase and follo...

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Authors: Dunn, C; Peppa, D; Khanna, P; Nebbia, G; Jones, M

• Publication status: Published
• Journal: Gastroenterology
• Volume: 137
• Issue: 4
• Pages: 1289-1300
• Publication date: 2009-10-01
• DOI: 10.1053/j.gastro.2009.06.054
• EISSN: 1528-0012
• ISSN: 0016-5085
• Language: English
• Keywords: Viral Load; Immunity, Innate; Interleukin-15; Male; Female; Time Factors; Interferon Type I; Cytokines; Viremia; Interleukins; Hepatitis B virus; Treatment Outcome; Acute Disease; T-Lymphocytes; Hepatitis B; Humans; Adult; Antiviral Agents; Killer Cells, Natural; Interleukin-10