Journal article
Fly Cell Atlas: a single-nucleus transcriptomic atlas of the adult fruit fly
- Abstract:
- The fruit fly Drosophila melanogaster has served as a premier model organism for discovering fundamental and evolutionarily conserved biological mechanisms. Combining recent advances in single-cell sequencing with powerful fly genetic tools holds great promise for making further discoveries. Li et al. present a single-cell atlas of the entire adult fly that includes 580,000 cells and more than 250 annotated cell types. Cells from the head and body recapitulated cell types from 15 dissected tissues. In-depth analyses revealed rare cell types, cell-type-specific gene signatures, and sexual dimorphism. This atlas provides a resource for the Drosophila community to study genetic perturbations and diseases at single-cell resolution. —BAP
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 41.5MB, Terms of use)
-
- Publisher copy:
- 10.1126/science.abk2432
Authors
- Publisher:
- American Association for the Advancement of Science
- Journal:
- Science More from this journal
- Volume:
- 375
- Issue:
- 6584
- Article number:
- 991
- Publication date:
- 2022-03-04
- Acceptance date:
- 2022-01-20
- DOI:
- EISSN:
-
1095-9203
- ISSN:
-
0036-8075
- Language:
-
English
- Keywords:
- Pubs id:
-
1233138
- Local pid:
-
pubs:1233138
- Deposit date:
-
2022-01-20
- ARK identifier:
Terms of use
- Copyright holder:
- Li et al
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
If you are the owner of this record, you can report an update to it here: Report update to this record