Journal article
Mph1 requires mismatch repair-independent and -dependent functions of MutSα to regulate crossover formation during homologous recombination repair
- Abstract:
-
In budding yeast the DNA helicase Mph1 prevents genome rearrangements during ectopic homologous recombination (HR) by suppressing the formation of crossovers (COs). Here we show that during ectopic HR repair, the anti-CO function of Mph1 is intricately associated with the mismatch repair (MMR) factor, MutSα. In particular, during HR repair using a completely homologous substrate, we reveal an MMR-independent function of MutSα in generating COs that is specifically antagonized by Mph1, but not...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Cancer Research UK
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Nucleic Acids Research Journal website
- Volume:
- 38
- Issue:
- 6
- Pages:
- 1889–1901
- Publication date:
- 2010-01-01
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:083415f6-615b-481c-897b-58f39e7eeed4
- Local pid:
- ora:8066
- Deposit date:
- 2014-02-24
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Terms of use
- Copyright holder:
- Ye Dee Tay, Julie M Sidebotham and Leonard Wu
- Copyright date:
- 2010
- Notes:
- © 2010 Ye Dee Tay, Julie M. Sidebotham and Leonard Wu. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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