Monitoring drug therapy.

Journal article

Drug development has improved over recent decades, with refinements in analytical techniques, population pharmacokinetic-pharmacodynamic (PK-PD) modelling and simulation, and new biomarkers of efficacy and tolerability. Yet this progress has not yielded improvements in individualization of treatment and monitoring, owing to various obstacles: monitoring is complex and demanding, many monitoring procedures have been instituted without critical assessment of the underlying evidence and rational...

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Authors: Buclin, T; Gotta, V; Fuchs, A; Widmer, N; Aronson, J

• Publication status: Published
• Journal: British journal of clinical pharmacology
• Volume: 73
• Issue: 6
• Pages: 917-923
• Publication date: 2012-06-01
• DOI: 10.1111/j.1365-2125.2012.04237.x
• EISSN: 1365-2125
• ISSN: 0306-5251
• Language: English
• Keywords: Models, Biological; Clinical Trials as Topic; Humans; Pharmaceutical Preparations; Dose-Response Relationship, Drug; Pharmacokinetics; Biological Markers; Pharmacology; Drug Design; Drug Monitoring