Journal article icon

Journal article

Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1{alpha} localization in erythroblasts.

Abstract:

Congenital dyserythropoietic anemia type 1 (CDA-1), a rare inborn anemia characterized by abnormal chromatin ultrastructure in erythroblasts, is caused by abnormalities in codanin-1, a highly conserved protein of unknown function. We have produced 3 monoclonal antibodies to codanin-1 that demonstrate its distribution in both nucleus and cytoplasm by immunofluorescence and allow quantitative measurements of patient and normal material by Western blot. A detailed analysis of chromatin structure...

Expand abstract

Actions


Access Document


Authors


Expand authors...
Journal:
Blood
Volume:
117
Issue:
25
Pages:
6928-6938
Publication date:
2011-06-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:081fb042-21d5-441a-86fd-ba19999f474e
Source identifiers:
124882
Local pid:
pubs:124882

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP