Mechanisms of particle-induced pulmonary inflammation in a mouse model: exposure to wood dust.

Journal article

Repeated airway exposure to wood dust has long been known to cause adverse respiratory effects such as asthma and chronic bronchitis and impairment of lung function. However, the mechanisms underlying the inflammatory responses of the airways after wood dust exposure are poorly known. We used a mouse model to elucidate the mechanisms of particle-induced inflammatory responses to fine wood dust particles. BALB/c mice were exposed to intranasally administered fine (more than 99% of the particle...

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Authors: Määttä, J; Lehto, M; Leino, M; Tillander, S; Haapakoski, R

• Journal: Toxicological sciences : an official journal of the Society of Toxicology
• Volume: 93
• Issue: 1
• Pages: 96-104
• Publication date: 2006-09-01
• DOI: 10.1093/toxsci/kfl026
• EISSN: 1096-0929
• ISSN: 1096-6080
• Language: English
• Keywords: DNA Primers; Pneumonia; Wood; Mice; Bronchi; Lung; Animals; Mice, Inbred BALB C; Female; Methacholine Chloride; Dust; Cytokines; Base Sequence; Receptors, Chemokine