The brain ages optimally to model its environment: evidence from sensory learning over the adult lifespan

Journal article

The aging brain shows a progressive loss of neuropil, which is accompanied by subtle changes in neuronal plasticity, sensory learning and memory. Neurophysiologically, aging attenuates evoked responses--including the mismatch negativity (MMN). This is accompanied by a shift in cortical responsivity from sensory (posterior) regions to executive (anterior) regions, which has been interpreted as a compensatory response for cognitive decline. Theoretical neurobiology offers a simpler explanation for all of these effects--from a Bayesian perspective, as the brain is progressively optimized to model its world, its complexity will decrease. A corollary of this complexity reduction is an attenuation of Bayesian updating or sensory learning. Here we confirmed this hypothesis using magnetoencephalographic recordings of the mismatch negativity elicited in a large cohort of human subjects, in their third to ninth decade. Employing dynamic causal modeling to assay the synaptic mechanisms underlying these non-invasive recordings, we found a selective age-related attenuation of synaptic connectivity changes that underpin rapid sensory learning. In contrast, baseline synaptic connectivity strengths were consistently strong over the decades. Our findings suggest that the lifetime accrual of sensory experience optimizes functional brain architectures to enable efficient and generalizable predictions of the world.

Authors: Moran, R; Symmonds, M; Dolan, R; Friston, K

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Public Library of Science
• Journal: PLoS Computational Biology
• Volume: 10
• Issue: 1
• Pages: e1003422
• Publication date: 2014-01-23
• Acceptance date: 2013-11-01
• DOI: 10.1371/journal.pcbi.1003422
• EISSN: 1553-7358
• ISSN: 1553-734X
• Language: English
• Keywords: Magnetoencephalography; Auditory Cortex; Cerebral Cortex; Middle Aged; Humans; Adult; Neuronal Plasticity; Brain; Learning; Brain Mapping; Algorithms; Models, Theoretical; Neurons; Aged; Aging; Male; Reproducibility of Results; Female; Bayes Theorem; SBTMR; Cohort Studies; Aged, 80 and over; Young Adult