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Metabolic consequences of the cytochrome c oxidase deficiency in brain of copper-deficient Mo(vbr) mice.

Abstract:

Biochemical micromethods were used for the investigation of changes in mitochondrial oxidative phosphorylation associated with cytochrome c oxidase deficiency in brain cortex from Mo(vbr) (mottled viable brindled) mice, an animal model of Menkes' copper deficiency syndrome. Enzymatic analysis of cortex homogenates from Mo(vbr) mice showed an approximately twofold decrease in cytochrome c oxidase and a 1.4-fold decrease in NADH:cytochrome c reductase activities as compared with controls. Asses...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
Journal of neurochemistry
Volume:
72
Issue:
4
Pages:
1580-1585
Publication date:
1999-04-05
DOI:
EISSN:
1471-4159
ISSN:
0022-3042
URN:
uuid:08169931-3667-4a13-872a-0f5ee6be580f
Source identifiers:
381499
Local pid:
pubs:381499

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